HESI Programs and Activities

HESI Emerging Issues Process

The Emerging Issues process provides a mechanism to assist HESI in identifying emerging scientific issues related to human health and environmental safety of chemicals, pharmaceuticals, and consumer products. Topics of potential interest are identified through an annual survey of the corporate membership and key contacts in academia, government and the public sector. Emphasis is placed on ensuring international input to this process from a broad range of sectors. Topics are prioritized in the first quarter of each year and exploratory meetings held to determine the interest in and potential scope of activities. If warranted, an Emerging Issues Subcommittee is established to propose and develop a program of scientific activities. Detailed information on these subcommittees can be found by clicking on the subcommittee name.

Emerging Issues Subcommittees

• Quantitative Pharmacokinetic Methods for Dosimetry Determinations 
• Risk Assessment for Sensitive Populations
• Emergence of Animal Alternative Needs in Environmental Risk Assessment

Project Committees and Technical Committees

The HESI Board of Trustees approves the formation of Technical Committees and Project Committees.  These committees typically evolve from Emerging Issues Subcommittees, and may support scientific research as well as sponsor symposia and workshops at which current scientific developments are presented and discussed. Detailed information on these committees can be found by clicking on the committee.

Project Committees

• Biological Significance of DNA Adducts
• Cancer Hazard Identification Strategies
• Cardiovascular Pro-Arrhythmia Models
• Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals
• Nanomaterial Environmental, Health, and Safety
• PPAR Agonist
• Relevence and Follow-up of Positive Results in In Vitro Genetic Toxicity Testing

Technical Committees

• Application of Genomics to Mechanism-based Risk Assessment
• Development and Application of Biomarkers of Toxicity 
• Developmental and Reproductive Toxicology 
• Immunotoxicology
• Integration of Biomonitoring Exposure Data into the Risk Assessment Process
• Non-Clinical/Clinical Safety Correlations Technical Committee
• Protein Allergenicity Technical Committee 
• Risk Assessment Methodologies (RAM)

Previous HESI Activities and Sunsetted Committees

As programs fulfill their mission and objectives, final products are published and committees may disband.

• Agricultural Chemical Safety Assessment (ACSA) 

Previous HESI activities have included the workshop series on mouse liver tumors and peroxisome proliferation, the Mouse Liver Tumorigenesis Postdoctoral Fellowship Program, the Water Quality Technical Committee and the Alternatives to Animal Testing Technical Committee.  For information about these programs, contact the HESI office at hesi@hesiglobal.org.