The mission of the HESI Cancer Hazard Identification Strategies (CHIS) Project Committee's is to consider new strategies that can offer an improvement in the process of identifying potential human carcinogens using a comprehensive data-based approach, taking into account dose-response and mode of action in the test system.
The Project Committee's specific objectives are three-fold:
- Provide a forum for government, academia, and industry to consider alternative approaches to identification of potential human cancer hazards. The focus of these discussions will be on the scientific validity of alternative strategies for identifying potential human carcinogens based on a comprehensive evaluation of available data.
- Evaluate the value and robustness of alternative approaches based on a sound assessment of available data.
- Propose additional experimental approaches for assessing the validity of alternative strategies.
Established by the HESI membership through the emerging issues process in January 2004, the Subcommittee met twice in 2004 to define its objectives, establish leadership, identify and confirm participants, and propose projects.
The Project Committee proposes to define a minimum data set necessary to identify a potential human cancer hazard. In so doing, alternative strategies will be carefully assessed. Among the Subcommittee’s anticipated deliverables are:
- a data-based assessment of alternative strategies for identification of potential human cancer hazards;
- a publicly available database which supports progress in the field;
- an open workshop at which the outcome of the Subcommittee’s assessments will be presented, available data will be reviewed, and implications and potential new directions will be discussed; and
- one or more publications in the scientific, peer-reviewed literature.
For more information on the Subcommittee’s membership, goals, and activities, click here.
Files
Download the English version of Cancer Hazard Identification Strategies Project Committee fact sheet here