On October 27-28, 2008, the HESI Application of Genomics to Mechanism-based Risk Assessment Committee hosted a workshop entitled, “Genomics Applications in Safety Studies - Case Study Workshop.”  The goal of this workshop was to summarize the state of the art, impacts, and perceptions of the application of genomics technologies in safety assessment and industry-related research.  The workshop discussions identified key questions and gaps that needed to be resolved to improve future safety assessments.