® HESI Emerging Issues Survey - Request for Submissions!
UPCOMING EVENTS
® The HESI Technical Committee on Application of Genomics to Mechanism-based Risk Assessment will sponsor a two-day workshop on “Genomics Applications in Safety Studies” in Arlington, Virginia on October 27-28, 2008. Click here for more information.
® Registration: Society of Toxicology Contemporary Concepts in Toxicology Workshop on “Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance”
PAST EVENTS
® ILSI Annual Meeting, January 18-24, 2007, Puerto Rico
® HESI Weight of Evidence Project Symposium at SRA Meeting, Dec 9-12, 2007
® HESI Genomics Committee Symposium, Nov 7-8, 2007
® HESI IVGT Subcommittee co-sponsors workshop at EMS, October 20, 2007
® HESI & ILSI Europe Booth at 2007 Eurotox Meeting, Oct 7-10, 2007
® HESI Presentations at 2007 Eurotox Meeting, Oct 7-10, 2007
® HESI Immunotoxicology Committee Meeting, Oct 1-3, 2007
® HESI Non-Clinical / Clinical Safety Correlations Meeting, Sept 20-21, 2007
® HESI at Eleventh International Congress of Toxicology – Montréal, Canada, July 15-19, 2007
® HESI Developmental and Reproductive Toxicology Technical Committee Platform Sessions, June 24, 2007
® HESI In Vitro Genetic Toxicity (IVGT) Testing Workshop, June 5-6, 2007
® HESI Biomarkers Committee ‘Mini-Symposium’ at FDA, Apr 11, 2007
HESI Weight of Evidence Project Symposium at SRA Meeting, Dec 9-12, 2007
The Risk Assessment Methodologies Technical Committee presented a symposium entitled, “Approaches to weight of evidence evaluation in risk assessment: A HESI Initiative” at the 2007 Society of Risk Analysis Annual Meeting, December 9-12 in San Antonio, TX. The symposium summarized the proceedings of the committee’s December 2006 international, multi-sector workshop, which provided a public forum for the exchange of information on various approaches to weight of evidence analysis within the context of risk assessment. The symposium offered four talks, which provided an introduction to the weight of evidence concept and methodologies, several different regulatory perspectives on the use of weight of evidence, recommendations for a research agenda, and some perspective and future directions for the HESI Weight of Evidence project. Click here for further information about this symposium and the committee activities.
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HESI Genomics Committee Symposium, Nov 7-8, 2007
This November 7-8, 2007 meeting featured the HESI Genomics Committee’s first public release of results from its four 2005-2007 research programs. The presentations covered: a) insights into ‘noisy’ and ‘quiet’ baseline gene expression as evaluated in a novel database of control rodent microarray data from liver/kidney; b) results from a 6 week rodent cardiotoxicity study designed by the Committee to explore the relationship between traditional toxicity measures (e.g., histopathology and clinical chemistry) and more recent mechanistic/toxicity tools (e.g., gene microarray and cardiac troponin data); c) outputs from a multi-lab pilot studying using RT-PCR and microarray to identify gene sets capable of distinguishing direct and in-direct acting genotoxins; and finally, d) a report on the variation in applications of and perceptions about microarray technologies in different sectors and job categories according to the Committee’s online survey of over 100 scientists. Day 2 of the meeting focused on identification of new research priorities for the Committee for 2008. The meeting was held at the Westin Washington Hotel and was open to the public, however advance registration is required. Click here for more information.
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HESI IVGT Subcommittee co-sponsors workshop at EMS, October 20, 2007
The HESI Emerging Issues Subcommittee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity (IVGT) Testing co-sponsored a workshop at the 2007 EMS Annual Meeting in Atlanta, Georgia entitled "On-Going Initiatives in Genetic Toxicology Testing and Risk Assessment.” The workshop covered a number of ongoing regulatory and multi-stakeholder initiatives in genotoxicity assessment, including the HESI IVGT Subcommittee. Bhaskar Gollapudi (The Dow Chemical Company), co-chair of the HESI IVGT Subcommittee, chaired the workshop and presented information on behalf of the HESI subcommittee. For the full workshop agenda, click here.
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HESI Immunotoxicology Committee Meeting, Oct 1-3, 2007
The HESI Immunotoxicology Technical Committee conducted an "Immunogenicity Roundtable" as part of a joint meeting on the "Nonclinical Safety Evaluation of Biopharmaceuticals," in Lyon, France, on October 1-3, 2007. Immunogenicity evaluation in preclinical vs clinical studies was addressed, as was types and practical applications of immunogenicity assays. Case studies were presented. The roundtable is part of the annual “Summer School in Immunotoxicology,” which also includes an International Conference on Harmonisation session. Click here for further information on the Roundtable and the joint meeting.
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HESI Non-Clinical/Clinical Safety Correlations Meeting, Sept 20-21, 2007
The HESI Non-Clinical / Clinical Safety Correlations Technical Committee hosted a workshop on September 20-21, 2007 in Washington, DC to develop a better understanding of the extent to which toxicities manifested in preclinical animal studies correlate with those seen in clinical trials. Click here for further information.
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HESI at Eleventh International Congress of Toxicology – Montréal, Canada, July 15-19, 2007
HESI co-sponsored a session entitled “Nanomaterials: Evaluating The Benefits And The Risks,” with the American College of Toxicology on July 19, 2007, as part of the Eleventh International Congress of Toxicology at the Palais des Congrès de Montréal, Montréal, Canada. The session was chaired by HESI Executive Director, Dr. Michael Holsapple.
HESI’s Board of Trustees also conducted its mid-year 2007 meeting immediately following the International Congress of Toxicology, enabling a number of HESI trustees to participate in the event, as well as the Nanomaterials session. HESI also shared information on its activities and programs via a booth in the Congress exhibition hall.
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HESI Developmental and Reproductive Toxicology Technical Committee Platform Sessions, June 24, 2007
The HESI Developmental and Reproductive Toxicology (DART) Technical Committee sponsored a platform session entitled “Application of Pharmacogenomics in Drug Development and Regulatory Science” at the 47th Annual Meeting of the Teratology Society, on June 24, 2007, in Pittsburgh, PA. This was the second such session sponsored by DART at the Teratology, following sponsorship at the 2006 meeting of a session on Regulatory Science. The committee will sponsor a session on vaccines at the 2008 meeting in Monterey, CA. Click here for further information on activities of the DART Technical Committee.
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HESI In Vitro Genetic Toxicity (IVGT) Testing Workshop, June 5-6, 2007
The HESI Emerging Issues Subcommittee on the Relevance and Follow-up of Positive Results in in Vitro Genetic Toxicity Testing (IVGT) held an international workshop June 5-6, 2007, in Washington, DC. The workshop was a follow-up to the subcommittee’s June, 2006 workshop, which examined ways to advance the basis for the interpretation of positive findings in in vitro assays, facilitate the development of follow-up testing strategies, and define criteria to determine the relevance to human health. The 2007 workshop participants discussed and expanded upon four potential sub-group topic areas, set goals and timelines, and worked to propose a path forward for the committee. The IVGT steering team is in the process of finalizing a workplan for the subcommittee and establishing membership for two main workgroups. Click here for more information on this committee.
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HESI Biomarkers Committee ‘Mini-Symposium’ at FDA, Apr 11, 2007
Senior leadership of the HESI Committee on Biomarkers of Toxicity presented an update on the Committee’s current and pending research programs on cardiac, testicular, and kidney biomarkers at FDA’s White Oak Headquarters on April 11, 2007. The session was attended by more than fifty FDA scientists from a variety of divisions. Click here to download abstracts from the presentations.
HESI Workshop on Alternative Assays for Developmental Toxicity, February 27-28, 2007
The Developmental and Reproductive Toxicology Committee of the ILSI Health and Environmental Sciences Institute (HESI) sponsored a two-day workshop to foster improvements in alternative models of developmental toxicity. Breakout groups covered stem cells, whole embryo culture, zebrafish, and the statistical methods used to turn short-term or in vitro observations into predictions of mammalian developmental toxicity. The workshop was held Feb 27-28, 2007, at the Umstead Hotel, in Raleigh (Cary), North Carolina, USA. For further information, contact Ms. Regina Graham at HESI (rgraham@hesiglobal.org), or click here to visit the Workshop webpage.
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HESI Approaches to Weight of the Evidence Evaluation in Risk Assessment, December 7-8, 2006
The ILSI Health and Environmental Sciences Institute (HESI) Risk Assessment Methodologies Technical Committee held a workshop on "Approaches to Weight of the Evidence Evaluation in Risk Assessment" on December 7th and 8th in Baltimore, MD. This international, multi-sector workshop provided a public forum for the exchange of information on approaches to weight of evidence analysis within the context of risk assessment. Goals of the meeting included identification and characterization of the current uses of weight of evidence analysis in human health risk assessment associated with Federal policy or regulatory decision making, and exploration of commonalities and differences in the application or understanding of weight of evidence analysis (more).
Joint HESI / ILSI Research Foundation/ ILSI International Food Biotechnology Committee (IFBiC) / ILSI Europe Workshop to Explore the Effects of Food Processing on Allergenicity, June 19-21, 2006, Estoril, Portugal.
The primary objective of this workshop was to evaluate the effects of processing on the stability, expression, and allergenic potential of endogenous and novel proteins in food. For more information on the workshop, including background information and a workshop program, click here.
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HESI / JRC / SETAC-Europe Workshop on Bioaccumulation Assessments
May 5-6, 2006, the Hague, the Netherlands
HESI Sera Bank Expert Workshop
April 25-27, 2006, Seoul, Korea
The ILSI Health and Environmental Sciences Institute’s (HESI) Development of Methods for a Tiered Approach to Assess Bioaccumulation of Chemicals Subcommittee and the Society of Environmental Toxicology and Chemistry (SETAC) jointly hosted a workshop March 3-4, 2006 to explore the range of in vitro techniques which may be applied to evaluate the bioaccumulation potential of chemicals. Click here for more information.
HESI In Vitro ADME Bioaccumulation Workshop
3/3/2006 - 3/4/2006, San Diego Marriott Hotel and Marina - San Diego, CA
Moving Towards Better Predictors of Drug-Induced Torsades de Poite (TdP) Workshop
On November 2-3, 2005, the HESI Cardiovascular (CV) Pro-Arrhythmia Models Project Committee hosted a workshop in Crystal City, VA. The workshop was organized to develop a better fundamental understanding of the emerging science, trends, and methods for predicting drug-induced TdP. The specific objectives for the workshop included identifying the underlying mechanisms for drug-induced TdP, evaluating emerging non-clinical methodologies for predicting drug induced TdP, and identifying short and long-term priorities for developing better predictors for drug-induced TdP. For more information on this workshop click on the above linked title.
HESI Workshop on Framework Approaches to Risk Assessment - Registration Information
11/14/2005 - 11/16/2005, Le Meridien Hotel - Nice, France
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