Workshop #2:  Agricultural Chemical Safety Assessment
9:00 am – 3:00 pm

In 2004, the HESI Technical Committee on Agricultural Chemical Safety Assessment (ACSA), an international group of government, academic, and industry scientists, completed a multi-year project to develop an improved testing strategy for assessing the safety of crop protection chemicals.  The tiered testing approach integrates metabolic and kinetic data into the safety assessment process; takes an integrated approach to evaluating life stage effects, systemic toxicity, and kinetics; and is guided by human exposure predictions.  During this workshop, leaders of the ACSA Technical Committee will describe the tiered testing strategy and its underlying scientific basis, logic, and flexibility.  In addition, speakers will quantify the reduction in the number of experimental animals required to perform a sound assessment using this approach and summarize government reception to the proposal to date.

Tentative Program

Welcome and Introduction:
Nancy G. Doerrer, MS (HESI) (confirmed)

Speakers:

     Chair:  Dr. Neil Carmichael (Bayer CropScience) (confirmed)

ADME
          Dr. Hugh Barton (US Environmental Protection Agency National Center for Computational Toxicology) (confirmed)
Systemic Toxicity
          Dr. John Doe (Syngenta CTL) (confirmed)
Life Stage
          Ms. Lorraine Irvine (toXcel International) (confirmed)
Integration of Approaches
          Dr. Neil Carmichael (Bayer CropScience) (confirmed)
US Government Perspective
          Dr. Vicki Dellarco (US Environmental Protection Agency Office of Pesticide Programs) (confirmed)
"OECD Perspective" Dr. Drew Wagner (Organisation for Economic Cooperation and Development (confirmed)

     Panel Discussion:

Moderator:  Prof. Alan Boobis (Imperial College London) (confirmed)
Rapporteur:  Dr. Angelo Moretto (University of Padua) (confirmed)

Panelists: 
Dr. Vicki Dellarco (US Environmental Protection Agency Office of Pesticide Programs) (confirmed)
European Food Safety Authority Representative (invited)
Dr. Claire Franklin (University of Ottawa; formerly with Health Canada) (confirmed)
Dr. James Klaunig (Indiana University School of Medicine) (confirmed)
Dr. Roland Solecki (Federal Institute for Risk Assessment, Berlin) (confirmed)
Dr. Drew Wagner (Organisation for Economic Cooperation and Development)(confirmed)