Agricultural Chemical Safety Assessment (ACSA) Technical Committee


The mission of the HESI Agricultural Chemical Safety Assessment (ACSA) Technical Committee was to develop a consensus across sectors (government, academia, and industry) on a credible and viable testing approach for assessing the safety of crop protection chemicals.  The approach included scientifically appropriate studies that are necessary without being redundant, emphasized toxicological endpoints and exposure durations that are relevant for risk assessment, provided greater efficiency, used fewer animals, used resources more wisely, and generally included improved data for risk assessment purposes.

Click here to download OECD Test Guideline 443 on the Extended One-Generation Reproductive Toxicity
Study, which was based on the HESI ACSA tiered testing approach to life stages toxicity.

 Committee Factsheet
 Committee Publications
 Committee Events
 Committee Presentations


Committee Participation

2007 Government and Academic Participants
CIIT Centers for Health Research, European Commission
Federal Institute for Risk Assessment (Germany)
Imperial College London
INRA (France)
Johns Hopkins University Center for Alternatives to
     Animal Testing
Medical College of Wisconsin
Michigan State University
Mississippi State University
National Institute of Public Health and the
     Environment (RIVM, Netherlands)
Organisation for Economic Cooperation and Development
Pacific Northwest National Laboratory
Universitá di Padua
University of California (Riverside)
University of Nottingham
University of Southampton
toXcel International Ltd.
Tox Path Inc.
US Environmental Protection Agency
     Office of Pesticide Programs
     National Center for Environmental Assessment
     National Health and Environmental Effects Research Laboratory
The Weinberg Group Inc.

2007 Committee Membership
BASF Corporation
Bayer CropScience
Dow AgroSciences
DuPont Crop Protection
Monsanto Company
Syngenta Ltd.



Neil Carmichael, PhD
Bayer CropScience

Timothy Pastoor, PhD
Syngenta Crop Protection

Nancy G. Doerrer, MS,
Ms. Cyndi Nobles,


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