Workshop on the Assessment of Respiratory Sensitization
Sensitization of the respiratory tract has significant acute and chronic health implications. While the existence of inducers of respiratory sensitization is widely recognized for some classes of chemical, validated standard methods or frameworks for identifying and characterizing the hazard are not available. This workshop aims to (1) discuss the current state of science for identification and characterization of respiratory sensitizer hazard, (2) identify the near-term and long-term information to facilitate development of validated standard methods and frameworks, and (3) consider the regulatory and practical needs regarding hazard management.
28-29 May 2014
Westin Hotel Alexandria
400 Courthouse Square
Alexandria, VA 22314
- What is current state of science for assessment of respiratory sensitizers?
- What are the most relevant immunological mechanisms with regard to sensitization and respiratory allergy?
- What are the relevant real world exposure conditions in the consumer and occupational realm?
- How do we define the condition for respiratory allergens in terms of elicitation vs. sensitization; what defines or represents the adverse outcome?
- What models are available to assess respiratory sensitizers?
- Are there approaches (e.g., single tests or tiered testing strategies) available for: (A) hazard identification chemical respiratory allergens and (B) their relative potency?
- Are there thresholds for sensitization and elicitation, and if so can they be measured?
- Do chemical respiratory allergens have unique physicochemical/structural characteristics?
- Can repeat dose toxicity studies inform assessment of the potential for respiratory allergy? How can various forms of data of contribute to a weight of evidence for respiratory allergy?
Colin North - ExxonMobil Biomedical Sciences
Ian Kimber - University of Manchester
Susan Tarlo - University of Toronto
Ian Kimber - University of Mancherster
Janine Ezendam - National Institute for Public Health and the Environment (RIVM), Netherlands
Jurgen Pauluhn - Bayer Pharma
In vivo and in vitro models for Prediction of Respiratory Sensitizers
Kohji Aoyama - Kogashima University
Erwin Roggen - 3Rs Consulting/Novozymes
Jon Htchkiss - The Dow Chemical Company
Steven Enoch - Liverpool Hohn Moores University
Cynthia Grahm - Huntsman, LLC
MaryJane Selgrade - IFC International
Antti Karjalainen - European Chemicals Agency
For more information, contact Dr. Connie Chen (firstname.lastname@example.org.)